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Role of preoperative immunonutrition in patients with colorectal cancer: a narrative review
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Soo Young Lee, Hyeung-min Park, Chang Hyun Kim, Hyeong Rok Kim
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Ann Clin Nutr Metab 2023;15(2):46-50. Published online August 1, 2023
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DOI: https://doi.org/10.15747/ACNM.2023.15.2.46
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Abstract
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- Purpose: Colorectal cancer surgery presents challenges due to surgical stress and immunosuppression, leading to postoperative complications. Nutrition is crucial for colorectal cancer patients who are prone to malnutrition. This study aims to provide a comprehensive review of the role of preoperative immunonutrition in colorectal cancer surgery.
Current concept: Preoperative immunonutrition, consisting of immunonutrients such as arginine, ω-3 fatty acids, and nucleotides, has emerged as a potential strategy to enhance surgical outcomes by modulating immune responses and reducing complications. Current guidelines recommend preoperative oral nutritional supplements for major abdominal surgery and immunonutrition for nutritionally high-risk patients. Meta-analysis have demonstrated significant decreases in infectious complications and hospital stay durations with preoperative immunonutrition. However, limitations such as publication bias and heterogeneity in the previous studies should be considered. Further research should focus on the optimal timing, duration, and amount of immunonutrition; the patient populations that would benefit most; and the integration of immunonutrition into enhanced recovery after surgery protocols. Conclusion: While preoperative immunonutrition shows promise, additional research is crucial to refine protocols and establish optimal clinical practice utilization.
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Enhanced Recovery After Surgery is Feasible in Laparoscopic Low Anterior Resection for Rectal Cancer
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Jeong Seon Jo, Soo Young Lee, Hun Jin Kim, Chang Hyun Kim, Young Jin Kim, Hyeong Rok Kim
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Surg Metab Nutr 2015;6(1):11-15. Published online June 30, 2015
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DOI: https://doi.org/10.18858/smn.2015.6.1.11
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Abstract
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Purpose:The aim of this study was to compare short-term outcomes in patients who underwent laparoscopic assisted low anterior resection for colorectal cancer. The patients received either conventional perioperative care or the Enhanced Recovery After Surgery (ERAS) procedural care. Materials and Methods:A retrospective review was conducted in patients who underwent elective laparoscopic low anterior resection for colorectal cancer between May, 2011 and December, 2013. Patients were grouped and analyzed according to the perioperative care program of ERAS and conventional care. Results:A total of 81 patients received care via the ERAS pathway and 230 patients received care via conventional pathway. There was no significant difference in postoperative morbidity rates (P=0.381). The post-operative morbidity rates were 30.9% and 25.2% in the ERAS and conventional groups. No significant difference in hospital stay (9.0±6.8 vs. 8.6±3.5 days; P=0.575) was observed between the 2 groups. Conclusion:No short-term perioperative disadvantages were found for the ERAS program compared with the conventional perioperative care for colorectal cancer patients who underwent laparoscopic low anterior resection. (Surg Metab Nutr 2015;6:11-15)
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