Annals of Clinical Nutrition and Metabolism

Original Articles

Development and Internal/External Validation of a Prediction Model for Weight Loss Following Gastric Cancer Surgery: A Multicenter Retrospective Study: Ji-Hyeon Park, Seong-Ho Kong, Do Joong Park, Han-Kwang Yang, Jong Won Kim, Ki Bum Park, In Cho, Sun-Hwi Hwang, Dong-Wook Kim, Su Mi Kim, Seung-Wan Ryu, Seong Chan Gong, Pil Young Jung, Hoon Ryu, Sung Geun Kim, Chang In Choi, Dae-Hwan Kim, Sung-IL Choi, Ji-Ho Park, Dong Jin Park, Gyu-Yeol Kim, Yunhee Choi, Hyuk-Joon Lee; Ann Clin Nutr Metab 2022;14(2):55-65. Published online December 1, 2022; DOI: https://doi.org/10.15747/ACNM.2022.14.2.55

Purpose: To develop an individualized model for predicting the extent of unintentional weight loss following gastrectomy in patients with gastric cancer based on related risk factors and to externally validate this model using multicenter clinical data in Korea.
Materials and Methods: Among gastric cancer patients who underwent curative gastrectomy at 14 different gastric cancer centers, clinical data from patients with more than one weight measurement during the three-year follow-up period were retrospectively collected. Risk factors associated with weight loss in gastric cancer patients after gastrectomy were analyzed, and a predictive model was developed. Internal and external validation were performed.
Results: The data from 2,649 patients were divided into a derivation set (n=1,420 from Seoul National University Hospital) and validation set (n=1,229 from 13 different gastric cancers). Postoperative duration (six vs. 12, 24, or 36 months), sex (female vs. male), age, preoperative body mass index, type of surgery (pylorus-preserving vs. total, distal or proximal gastrectomy), and cancer stage (I vs. II or III) were included in the final prediction model. The model showed approximately 20% accuracy in predicting weight loss at each period: R2 at six, 12, 24 and 36 months after gastrectomy in internal validation=0.20, 0.21, 0.17, and 0.18, respectively, and in external validation=0.20, 0.22, 0.18, and 0.18, respectively. Calibration slopes of internal and external validation were 0.95 and 1.0, respectively.
Conclusion: Although predictive accuracy of the model did not reach an acceptable level, repeated external validation measurements showed high reliability. The model may serve as a basic reference in clinical practice.

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Development and Feasibility Assessment of Mobile Application-Based Digital Therapeutics for Postoperative Supportive Care in Gastric Cancer Patients Following Gastrectomy
Ji-Hyeon Park, Hyuk-Joon Lee, JeeSun Kim, Yo-Seok Cho, Sunjoo Lee, Seongmin Park, Hwinyeong Choe, Eunhwa Song, Youngran Kim, Seong-Ho Kong, Do Joong Park, Byung-Ho Nam, Han-Kwang Yang
Journal of Gastric Cancer.2024; 24(4): 420. CrossRef

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Risk Factor of Anemia after a Gastrectomy in Patients with Gastric Cancer: In Jun Yang, Dong-Wook Kim, Ye Seob Jee; Surg Metab Nutr 2019;10(1):15-19. Published online June 30, 2019; DOI: https://doi.org/10.18858/smn.2019.10.1.15

Abstract PDF

Purpose:

In this study, we evaluate hematologic change of iron and vitamin B₁₂ on post-operative anemia after gastrectomy for gastric cancer.

Materials and Methods:

The patients with gastric cancer who underwent gastrectomy between January 2013 and December 2013 in Dankook university hospital were retrospectively reviewed. The 62 patients were followed up for 36 month postoperatively.

Results:

The incidences of anemia in female patients were turned out to be higher than those in male patients but there were no statistical difference; (44.4% vs 40.9%, P=0.399) at 6 month, (33.3% vs 25.0%, P=0.252) at 12 month, (22.2% vs 15.9%, P=0.277) at 18 month, (27.8% vs 15.9%, P=0.142) at 36 month after surgery. Patients with distal gastrectomy after the surgery showed decreasing incidence of anemia while patients with total gastrectomy showed decreasing incidence of anemia until 12 months but increasing incidence after that time.

Conclusion:

Anemia, Vitamin B₁₂ and iron deficiency must be evaluated after surgery for gastric cancer and active treatment is necessary as needed.