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Original Article
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The Efficacy and Safety of
Cordyceps militaris in Korean Adults Who Have Mild Liver Dysfunction - Jin Young Heo, Hyun Wook Baik, Hyuk Jung Kim, Jae Min Lee, Hyung Woo Kim, Yong Sun Choi, Jung Ho Won, Hyun Mi Kim, Won Il Park, Chul Young Kim
- J Clin Nutr 2015;7(3):81-86. Published online December 31, 2015
- DOI: https://doi.org/10.15747/jcn.2015.7.3.81
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Abstract
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ePub Purpose:
The aim of this study is to determine the efficacy and safety of
Cordyceps militaris in Korean adults with mild liver dysfunction.C. militaris is a mushroom traditionally used for several clinical purposes in East Asian territory, including China, and has been found to be effective in improving liver function through animal studies.Methods:
The
C. militaris group was administered 1.5 g/day ofC. militaris (2 capsules per dose, twice per day) and the placebo group was administered the same volume of placebo. Laboratory test (white blood cell, hemoglobin, platelet, aspartate aminotransferase, alanine aminotransferase, gamma glutamyltranspeptidase, lactic dehydrogenase, alkaline phosphatase, total bilirubin, blood urea nitrogen, creatinine), liver computed tomography (CT) were performed, and visual analogue scale score for subjective symptoms and fatigue severity scale were measured.Results:
In analysis of the liver CT scan at 8 weeks after administration compared to baseline, the mean ratio of change of Hounsfield unit of 8 segments of liver increased by an average of 21.43%±45.11% in the
C. militaris group and 9.64%±11.41% in the placebo group. Others showed no statistically significant inter-group difference.Conclusion:
C. militaris extract was used safely as a functional food in patients with mild liver dysfunction, and is expected to protect against progression of fatty liver or cirrhosis caused by suppression of lipid accumulation in hepatocytes.-
Citations
Citations to this article as recorded by
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Bioactive compounds from
Cordyceps
and their therapeutic potential
Kondapalli Vamsi Krishna, Rutwick Surya Ulhas, Alok Malaviya
Critical Reviews in Biotechnology.2024; 44(5): 753. CrossRef - Cordyceps militaris: An Overview of Its Chemical Constituents in Relation to Biological Activity
Karol Jerzy Jędrejko, Jan Lazur, Bożena Muszyńska
Foods.2021; 10(11): 2634. CrossRef - Efficacy of Dietary Supplements to Reduce Liver Fat
Brittanie Kilchoer, Anina Vils, Beatrice Minder, Taulant Muka, Marija Glisic, Lia Bally
Nutrients.2020; 12(8): 2302. CrossRef - Change in Dietary Intake and Nutritional Status Using Mealworms as Hospital Meal in Postoperative Patie
Seong Hyeon Kim, Jin Young Shon, Jun Sung Park, Jong Won Kim, Jung Hyun Kang, Eun Young Yun, Jae Sam Hwang, Hyung Mi Kim
Journal of the Korean Dietetic Association.2016; 22(4): 292. CrossRef
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Bioactive compounds from
Cordyceps
and their therapeutic potential
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