Skip Navigation
Skip to contents

Ann Clin Nutr Metab : Annals of Clinical Nutrition and Metabolism

OPEN ACCESS

Search

Page Path
HOME > Search
2 "Selenium"
Filter
Filter
Article category
Keywords
Publication year
Authors
Review
Selenium deficiency and supplementation in infants: a narrative review
Ji Young Lee, Min Jung Kang, Hyun Jeong Kim, Sung Yun Suh, Yoon Sook Cho, Sook Hee An
Ann Clin Nutr Metab 2023;15(1):8-14.   Published online April 1, 2023
DOI: https://doi.org/10.15747/ACNM.2023.15.1.8
AbstractAbstract PDFePub
Purpose: This review aims to provide an overview of the factors and clinical outcomes associated with selenium deficiency and the guidelines on the optimal selenium supplementation in infants.
Current concept: Selenium is a cofactor required to maintain the activity of glutathione peroxidase and is an essential trace element in the human body. Selenium is involved in many stages of oxidative injury within the human body. In severe cases, selenium deficiency may lead to cardiomyopathy. Particularly in infants, the risk factors for selenium deficiency are preterm birth and long-term parenteral nutrition. Several studies have been conducted on the relationship between selenium deficiency and bronchopulmonary dysplasia, retinopathy of prematurity, and sepsis, all of which are common diseases in preterm infants. In the past, 2–3 mcg/kg/day of intravenous selenium supplementation was recommended in preterm infants with selenium deficiency. However, recent studies have suggested that only 2–3 mcg/kg/day can prevent further decreases of selenium level in the blood of preterm infants, and that higher supplementation of 1.5–4.5 mcg/kg/day or 7 mcg/kg/day is necessary to reach the level of healthy infants at term. The recommended dose of selenium through enteral nutrition for preterm infants is 1.3–4.5 mcg/kg/day or 5–10 mcg/kg/day, depending on the guideline.
Conclusion: Adequate selenium administration is required for adequate nutritional support in infants to prevent selenium deficiency, and more studies should be conducted to establish dosing guidelines considering risk factors in preterm infants.
  • 345 View
  • 14 Download
Close layer
Original Article
Relationship between Selenium Plasma Levels and Prognosis of Major Burn Patients
Seung Hyun Hwang, Tae Young Jang, Tae Young Jang, Hye Jung Han, Hye Jung Han, Go Woon Woo, Go Woon Woo
Surg Metab Nutr 2015;6(2):28-32.   Published online December 30, 2015
DOI: https://doi.org/10.18858/smn.2015.6.2.28
AbstractAbstract PDFePub

Purpose:

Selenium is an important trace element for antioxidative function. Low selenium plasma level in sepsis is associated with high oxidative damage and increasing consumption of selenium, which is thought to affect severity of burns. This study was conducted to investigate a relationship between selenium plasma levels and prognosis of burn patients.

Materials and Methods:

In a retrospective review of 45 burn patients with more than 20% TBSA from January 2011 to May 2015, selenium plasma levels on days 2 to 7 after burn injury, abbreviated burn severity index (ABSI), mortality, length of stay in intensive care unit, and duration of intravenous antibiotics use were measured.

Results:

Selenium plasma levels on days 2 to 7 after burn injury were fairly correlated with ABSI (r=-0.640, P<0.001), TBSA (r=-0.640, P<0.001), duration of intravenous antibiotics use (r=-0.555, P<0.001), and length of stay in intensive care unit (r=-0.445, P=0.004). In comparison between survivor and non-survivor, statistical difference was observed between two selenium plasma levels (66.2±13.6 mcg/L versus 49.4±14.5 mcg/L, P=0.002).

Conclusion:

In this study, selenium plasma levels on days 2 to 7 after burn injury was related to prognosis of major burn patients.

  • 93 View
  • 0 Download
Close layer

Ann Clin Nutr Metab : Annals of Clinical Nutrition and Metabolism
Close layer
TOP