Wernicke’s encephalopathy can develop from vitamin B1 (thiamine) deficiency and presents itself as ataxia, ophthalmoplegia, and mental confusion. One of its predisposing factors is long-term TPN. An adult patient with an entero-cutaneous fistula received total parenteral nutrition (TPN) for 2 months. After one month, the patient presented dizziness and ophthalmophlegia. The patient was diagnosed as thiamine deficient and subsequent thiamine administration brought dramatic recovery. To our knowledge, reports about Wernicke’s encephalopathy during long-term TPN are rare. (SMN 2010;1:42-44)