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- Special Contribution Multicenter, Prospective Randomized Controlled Trial Evaluating Postoperative Oral Nutritional Supplementation for Patients Who Underwent Major Gastrointestinal Surgery
- Seong-Ho Kong1, Seung Wan Ryu2, Jun Seok Park3, Ji Won Park1, Kyung Won Seo4, In Kyu Lee5, Mi Ran Jeong6, Dae Wook Hwang7, Hoon Hur8, Hyuk-Joon Lee1, Guideline and Clinical Trial Committee of the Korean Society of Surgical Metabolism and Nutrition
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주요 위장관 절제술을 시행한 환자에서 수술 후 경구영양보충요법의 임상적 의의에 대한 다기관, 전향적 무작위 대조연구(KSSMN-01) - 공성호1ㆍ류승완2ㆍ박준석3ㆍ박지원1ㆍ서경원4ㆍ이인규5ㆍ정미란6ㆍ황대욱7ㆍ허 훈8ㆍ이혁준1ㆍ대한외과대사영양학회 가이드라인/임상시험위원회
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Surgical Metabolism and Nutrition 2013;4(2):31-36.
Published online: December 30, 2013
1Department of Surgery, Seoul National University Hospital, Seoul, Korea,
2Department of Surgery, Keimyung University Dopngsan Medical Center, Daegu, Korea,
3Department of Surgery, Kyungpook National University Medical Center, Daegu, Korea,
4Department of Surgery, Kosin University Gospel Hospital, Busan, Korea,
5Department of Surgery, The Catholic University of Korea College of Medicine, Yeouido St. Mary's Hospital, Seoul, Korea,
6Department of Surgery, Chonnam National University Hwasun Hospital, Gwangju, Korea,
7Department of Surgery, Seoul National University Bundang Hospital, Seongnam, Korea,
8Department of Surgery, Ajou University Hospital, Suwon, Korea
1서울대학교병원 외과,
2계명대학교 동산의료원 외과,
3칠곡경북대학교병원 외과,
4고신대학교 복음병원 외과,
5가톨릭대학교 여의도성모병원 외과,
6화순전남대학교병원 외과,
7분당서울대학교병원 외과,
8아주대학교병원 외과
2Department of Surgery, Keimyung University Dopngsan Medical Center, Daegu, Korea,
3Department of Surgery, Kyungpook National University Medical Center, Daegu, Korea,
4Department of Surgery, Kosin University Gospel Hospital, Busan, Korea,
5Department of Surgery, The Catholic University of Korea College of Medicine, Yeouido St. Mary's Hospital, Seoul, Korea,
6Department of Surgery, Chonnam National University Hwasun Hospital, Gwangju, Korea,
7Department of Surgery, Seoul National University Bundang Hospital, Seongnam, Korea,
8Department of Surgery, Ajou University Hospital, Suwon, Korea
1서울대학교병원 외과,
2계명대학교 동산의료원 외과,
3칠곡경북대학교병원 외과,
4고신대학교 복음병원 외과,
5가톨릭대학교 여의도성모병원 외과,
6화순전남대학교병원 외과,
7분당서울대학교병원 외과,
8아주대학교병원 외과
Received: 3 December 2013 • Revised: 14 December 1901 • Accepted: 6 December 2013
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Abstract
Patients undergoing major gastrointestinal surgery are potentially at high risk of malnutrition, and oral nutritional supplement solutions have been commercialized as an easily edible balanced nutritional source. A multicenter prospective randomized study to examine the efficacy of postoperative oral nutritional supplementation is ongoing in Korea. A total of 174 patients in eight institutes who are supposed to undergo major gastrointestinal organ resection or significant bowel reconstruction will be prescreened before the operation, and randomized to either the oral nutrition supplementation group or the control group when they are discharged after the operation. After discharge, patients in the oral nutrition supplementation group take 200 ml of Encover? solution twice per day for eight weeks, thereafter the weight loss rate of each group compared with preoperative body weight will be compared with that of the control group as a primary endpoint. The secondary endpoints include weight loss rate compared with that at the time of discharge, changes of body mass index, biochemical serum parameters, patient-generated subjective global assessment, and anthropometric measurements (ClincalTrials.gov ID: NCT01838109). (SMN 2013;4:31-36)
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