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Physiological Change of Serum Bilirubin Level by ω-3 Enriched Parenteral Nutrition Versus ω-3 Free Parenteral Nutrition in Healthy Male Subjects
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Mi Rin Lee, Min-Gul Kim, Jae Do Yang, Hong Pil Hwang, Yunjeong Kim, Ji-Young Jeon, Sungwoo Ahn, Hee Chul Yu
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Surg Metab Nutr 2019;10(1):20-26. Published online June 30, 2019
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DOI: https://doi.org/10.18858/smn.2019.10.1.20
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 Abstract
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Purpose: Bilirubin is a biomarker for the diagnosis of liver diseases or bile duct dysfunction. This study assessed the physiological changes in the blood bilirubin level infusing ω-3 enriched parenteral nutrition (PN) and ω-3 free PN in healthy male subjects. Materials and Methods: This study was a randomized, open-label, two-treatment, two-way crossover trial. Sixteen subjects were assigned randomly to one of two sequences of the two treatments: ω-3 enriched PN or ω-3 free PN was infused via aperipheral venous catheter for six hours at 3 mL/kg/h. Blood samples were collected every one hour from 0 to 12 hours after starting an intravenous infusion for bilirubin concentrations. The total bilirubin and direct bilirubin concentrations in the blood were analyzed using an enzymatic method. Results: The bilirubin concentration in the blood was reduced while infusing the ω-3 enriched PN and ω-3 free PN. When it stopped infusing, the bilirubin concentration was recovered. A similar pattern was observed, but there was a further decline and recovery in ω-3 free PN. Conclusion: When ω-3 enriched PN and ω-3 free PN are infused in healthy male subjects, the blood bilirubin level decreasedand there is no difference between the two groups.
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