-
Muscle Protein Metabolism in Critically Illness
-
Min Chang Kang
-
Surg Metab Nutr 2020;11(2):35-39. Published online December 30, 2020
-
DOI: https://doi.org/10.18858/smn.2020.11.2.35
-
-
 Abstract
 PDF
- Most patients experience a considerable amount of muscle wasting during critical care. A decrease in muscle mass causes weakness which inevitably leads to delayed recovery. Since muscle also plays an important role in protein metabolism, metabolic instability increases as muscle mass decreases. Accordingly, various treatments have been attempted to maintain muscle mass and function in critically ill patients; however, it is still difficult to prevent muscle loss. It is known that muscle wasting in critical illness is primarily due to increased muscle protein breakdown rather than a decrease in muscle protein synthesis. Nutritional therapy and rehabilitation are fundamentally important, but additional anabolic agents may be needed to overcome anabolic resistance. In this review, we will learn about muscle protein metabolism in critically ill patients and how various treatments affect muscle protein metabolism.
-
Citations
Citations to this article as recorded by  - Combined intravenous bolus amino acid supplementation and mobilization on early muscle loss in critically ill adults: A randomized controlled trial
Lizl Veldsman, Guy A. Richards, Daniel Nel, Tertius A. Kohn, Renée Blaauw
Journal of Parenteral and Enteral Nutrition.2026; 50(2): 170. CrossRef - Reply to “Mechanical tension and autophagy suppression: Unmasking the confounders in ICU muscle preservation strategies”
Lizl Veldsman, Guy A. Richards, Daniel Nel, Tertius A. Kohn, Renée Blaauw
Journal of Parenteral and Enteral Nutrition.2026; 50(5): 640. CrossRef - Arterial Elasticity in Chinese Youth: References and the Role of Muscle
Hongbo Dong, Yan Li, Minjun Li, Xiangjun Xie, Pei Xiao, Yanyan Li, Lina Lan, Jingfan Xiong, Jie Mi
Hypertension.2026;[Epub] CrossRef - Efficacy and safety of higher versus lower protein provision with meaningful dose separation in critically ill adults: a systematic review and meta-analysis of randomized controlled trials
Yun Zhou, Xiuxiu Hao, Run Pan, Tiantian Li, Zhiliang Yang, Zheng Wang, Yi Xiao
Frontiers in Nutrition.2026;[Epub] CrossRef - Low protein content of plant-derived nutrition limits the protein transition in hospitalized patients: Results from an observational study
M.A. van Bree, B.C. Schouten, E.S. Wolters, M.R. Soeters, H.M. Kruizenga
Clinical Nutrition ESPEN.2025; 69: 311. CrossRef - Combined Protein, Probiotics, and Exercise Therapy for Sarcopenia: A Comprehensive Review
Ryuk Jun Kwon, Mohammad Al Mijan, Soo Min Son, Wanho Yoo, Taehwa Kim
Cells.2025; 14(17): 1375. CrossRef - Double-Edge Effects of Leucine on Cancer Cells
Burkitkan Akbay, Zhannur Omarova, Alexander Trofimov, Bayan Sailike, Orynbassar Karapina, Ferdinand Molnár, Tursonjan Tokay
Biomolecules.2024; 14(11): 1401. CrossRef - Compartmental analysis: a new approach to estimate protein breakdown and meal response in health and critical illness
Nicolaas E. P. Deutz, Mariëlle P. K. J. Engelen
Frontiers in Nutrition.2024;[Epub] CrossRef - Amino acid kinetics in the critically ill
Nicolaas E.P. Deutz, Krista L. Haines, Paul E. Wischmeier, Mariëlle P.K.J. Engelen
Current Opinion in Clinical Nutrition & Metabolic Care.2024; 27(1): 61. CrossRef
-
7,962
View
-
85
Download
-
9
Crossref
|
E-submission
KSPEN
KSSMN
ASSMN
JSSMN
