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- Definition, assessments, and current research on sarcopenia in children: a narrative review
- Min-Jung Bang
- Ann Clin Nutr Metab 2024;16(2):49-56. Published online August 1, 2024
- DOI: https://doi.org/10.15747/ACNM.2024.16.2.49
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Abstract
PDF - Purpose: Sarcopenia is a well-established prognostic factor for the clinical outcomes of adult patients with cancer and chronic diseases and correlates with increased intensive care unit admissions and prolonged hospital stays. However, research on sarcopenia in children is limited due to its undefined criteria and a lack of studies exploring its impact on clinical outcomes.
Current concept: The challenges in pediatric sarcopenia research include the absence of standardized body composition methods to quantify muscle mass and muscular function, as well as inconsistencies in definitions. Additionally, there is a lack of age- and gender-specific normative data, particularly for young children and infants. Most studies also lack assessments of muscle function, which can lead to bias and misclassification of sarcopenia. The field is further hindered by poor study quality, limited outcome-focused research, and a dearth of longitudinal data. While some studies suggest that various diseases can affect children’s lean muscle mass, few have linked changes in muscle mass to clinical outcomes.
Conclusion: The existing literature on pediatric sarcopenia and its relationship with medical and surgical outcomes is sparse and indicates poorer outcomes associated with sarcopenia. Although extensive research has established a link between sarcopenia and adverse outcomes in adults, information on its impact in pediatric populations remains scarce. Further studies are needed to elucidate the association between muscle mass and outcomes in pediatric surgical patients.
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Original Article
- Relationship of Sarcopenia with the Outcomes of Patients who Underwent Surgery for Bile Duct Cancer
- Hye Jin Kim, Min-Su Park, Bum-Soo Kim, Sang-Mok Lee
- Surg Metab Nutr 2019;10(2):54-58. Published online December 30, 2019
- DOI: https://doi.org/10.18858/smn.2019.10.2.54
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Abstract
PDF
Purpose:
This study investigated the impact of Sarcopenia by examining the psoas muscle on the outcomes after bile duct resection for bile duct cancer.
Materials and Methods:
This study retrospectively analyzed 101 patients who underwent surgery for bile duct cancer between January 2006 and December 2015 at Kyung-Hee University Hospital. Skeletal muscle mass was evaluated by performing preoperative computed tomography to define Sarcopenia. Patients were classified into two groups by the median value of the psoas muscle index (PMI).
Results:
The median value of the psoas muscle index in female patients was 463.9 mm2/m2, and the median value of the psoas muscle index in males was 688.7 mm2/m2. In the sarcopenia group, the 1, 3, and 5-year recurrence free survival rates were 74.5%, 52.9%, and 27.5%, respectively. On the other hand, in the non-sarcopenia group the 1, 3, and 5-year recurrence free survival rates were 50%, 34%, and 28%, respectively. In the sarcopenia group, the 1, 3, and 5-year overall survival rates were 84.3%, 54.9%, and 31.4%, respectively. In the non-sarcopenia group, 1, 3, and 5-year overall survival rates were 58%, 40%, and 32%, respectively. However, recurrence-free survival and overall survival were not correlated with sarcopenia (P=0.131, P=0.163).
Conclusion:
Sarcopenia using the psoas muscle index (PMI) has no impact on outcomes of bile duct cancer patients who underwent surgery. (Surg Metab Nutr 2019;10:-58)
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