Many pediatric patients, particularly those with short bow-el syndrome (SBS), will eventually require long-term pa-renteral nutrition in order to provide adequate nutritional support. This requires an extended hospital stay. We re-port on the case of a four-year-old boy with SBS who was administered home parenteral nutrition (HPN) during a period of 14 months. The goal of HPN therapy is to maintain the patient’s nutrition status while concurrently making all efforts to minimize complications associated with HPN. Central catheter infection did not occur during this period. Despite cyclic PN, liver function test (LFT) val-ue was sometimes increasing. After PN calorie was de-creased, LFT values were normalized. When evaluated according to the corrected age, he belonged to 5%∼25% for weight status, which was considered normal weight compared to height. For all patients requiring prolonged PN support, HPN is the only alternative to long-term hos-pitalization and may be the best option for improvement of patients’ quality of life. However, significant benefit can be gained through collaboration between healthcare pro-viders within the institution. Family training and education are important. Using this case, we evaluate the clinical experiences and considerations of HPN in Korea. (J Korean Soc Parenter Enter Nutr 2013;5(3):130-132)