Annals of Clinical Nutrition and Metabolism

Review

Efficacy of monounsaturated fatty acids in reducing risk of the cardiovascular diseases, cancer, inflammation, and insulin resistance: a narrative review: Ki Hyun Kim, Yoonhong Kim, Kyung Won Seo; Ann Clin Nutr Metab 2023;15(1):2-7. Published online April 1, 2023; DOI: https://doi.org/10.15747/ACNM.2023.15.1.2

Abstract PDF ePub: Purpose: The purpose of this review is to explore the potential benefits of monounsaturated fatty acids (MUFAs), specifically those found in olive oil, on weight loss, cardiovascular disease, cancer, inflammation, and insulin resistance. Additionally, this review examines the use of olive oil–based intravenous lipid emulsions (ILEs) in providing parenteral nutrition to patients with diverse needs.
Current concept: MUFAs, found in olive oil, nuts, and some animal foods, have been found to have numerous health benefits. A diet high in MUFAs can aid in weight loss and reduce the risk of cardiovascular disease. Olive oil, in particular, has been linked to a lower risk of cancer, inflammation, and insulin resistance. In addition, olive oil–based ILEs have been utilized for over two decades and are well tolerated by patients requiring parenteral nutrition.
Conclusion: A diet rich in MUFAs, specifically from olive oil, can provide numerous health benefits, including weight loss and reducing the risk of cardiovascular disease, cancer, inflammation, and insulin resistance. Additionally, olive oil–based ILEs have been shown to effectively provide nutrients to diverse populations requiring parenteral nutrition and have demonstrated the ability to preserve immune function and induce less lipid peroxidation than other ILEs. Further research is needed to fully understand the potential benefits of MUFAs and olive oil-based ILEs, but current evidence suggests that they may be a valuable addition to a healthy diet and medical treatment.

26 View
0 Download

Original Articles

Incidence of Potential Intravenous Drug Incompatibilities in the Intensive Care Units of a University Hospital: Sunmin Lee; J Clin Nutr 2020;12(1):14-20. Published online June 30, 2020; DOI: https://doi.org/10.15747/jcn.2020.12.1.14

Abstract PDF ePub: Purpose: Potential incompatibility (PI) between drugs infused together is frequent but under-recognized in intensive care units (ICU). This paper describes the frequency of the inappropriate coadministration of infused medications via the Y-site and identifies the most frequent and relevant drug incompatibilities in a single-center, cross-sectional observational study.
Methods: This research was a retrospective cross-sectional study of 100 patients conducted between July and December 2019 in an ICU. The medical records of 100 patients in the ICU were collected, and their compatibility was assessed based on published compatibility data.
Results: PI was detected in approximately 48.5% of patients (1.5 incompatibility/patient ratio). Most incompatibilities detected were classified as follows: the untested (84.4%), variable (9.7%), incompatibility (3.9%), or no data (1.9%). Acetylcysteine was the most frequent drug implied in PI. A difference was observed between the lengths of ICU and PI incidences (P=0.01). In the correlation between PI and APACHE II (Acute Physiology and Chronic Health Evaluation II), there was a weak correlation between APACHE II and PI (r=0.283, P<0.05).
Conclusion: PI is common in an ICU, with a higher prevalence of non-tested incompatibilities. The number of drugs and prescription of acetylcysteine, pantoprazole, meropenem piperacillin/tazobactam, or phytonadione are the risk factors for PI.

7 View
1 Download

Influence of Fish Oil-Containing Lipid Emulsions on Parenteral Nutrition-Associated Liver Disease in Neonates: Jeong-A Park, Ji-Eun Park, Min-Jae Jeong, Jae-Song Kim, Eun-Sun Son, Ho-Seon Eun; J Clin Nutr 2017;9(1):21-29. Published online June 30, 2017; DOI: https://doi.org/10.15747/jcn.2017.9.1.21

Abstract PDF Supplementary Material ePub: Purpose:
This study is a comparative evaluation of the incidence of parenteral nutrition-associated liver disease (PNALD) when administering intravenous fat emulsions containing fish oil.
Methods:
The medical records of patients who were in the neonatal intensive care unit at Severance Hospital from January, 2012 to December 2015, were reviewed retrospectively. Patients who were administered either soybean oil (SO) or SMOF (containing soybean oil, medium chain triglycerides, olive oil, and fish oil) more than 14 days were included. The patients were excluded if they were administered both agents or had underlying hepatic disease. An increase in bilirubin to 2 mg/dL was defined as PNALD.
Results:
PNALD occurred in only 8 out of a total of 77 patients: 6 out of 31 (19.4%) in the SO group and 2 out of 46 (4.3%) in the SMOF group (P=0.055). The number of patients, whose lab values, such as direct bilirubin, total bilirubin, asparate aminotransferase (AST), alanine amino-transferase, gamma-glutamyl transpeptidase, C-reactive protein, serum triglyceride, and alkaline phosphate, exceeded the normal range, were similar in both groups. The gestational age, birth body weight, and APGAR score at 1 min and 5 min were significantly higher in the SO group and the PN duration was significantly long in the SMOF group. Considering only term infants, there were no significant differences in baseline characteristics and incidence of PNALD. The number of patients whose AST exceeded the normal range was significantly higher in the SO group (P=0.034).
Conclusion:
The incidence of PNALD was similar in both groups. On the other hand, considering the tendency, there was a high correlation between the type of lipid emulsion and an increased direct bilirubin level in the SO group.

6 View
0 Download

First
Prev
Page of 1
Next
Last

Search

Purpose:

Methods:

Results:

Conclusion: