Annals of Clinical Nutrition and Metabolism

Perioperative outcomes of older adult patients with pancreatic cancer based on nutritional status: a retrospective cohort study: Takanori Morikawa, Masaharu Ishida, Masamichi Mizuma, Kei Nakagawa, Takashi Kamei, Michiaki Unno; Ann Clin Nutr Metab 2025;17(1):66-74. Published online April 1, 2025; DOI: https://doi.org/10.15747/ACNM.25.001

Purpose
This study investigated the effects of preoperative nutritional status on postoperative outcomes in older adult patients with pancreatic adenocarcinoma.
Methods
The background and perioperative factors of patients who underwent pancreatectomy for pancreatic adenocarcinoma between 2007 and 2020 were retrospectively analyzed.
Results
Patients aged 75 years or over (older adults) were significantly associated with hypertension, upfront surgery, and lower prognostic nutritional index. In addition, these patients had a significantly lower rate of portal vein resection, less blood loss, and shorter operation time than patients aged less than 75 years (non-older adults). During the postoperative course, older adult patients had a higher rate of pneumonia and lower overall survival than younger patients, although recurrence‐free survival was comparable. In addition, older adult patients showed preoperative malnutrition as a risk factor for postoperative in‐hospital death.
Conclusion
Surgical treatment for pancreatic cancer in older adult patients was performed safely. However, preoperative malnutrition is a risk factor for in‐hospital death and such patients require nutritional support and less‐invasive surgery.

Citations

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Strengthening collaboration: introducing the contributions of Japanese Society for Surgical Metabolism and Nutrition to Annals of Clinical Nutrition and Metabolism
Ye Rim Chang
Ann Clin Nutr Metab.2025; 17(2): 95. CrossRef

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Role of nutrition in wound healing and nutritional recommendations for promotion of wound healing: a narrative review: Myoungjean Ju, Yoonhong Kim, Kyung Won Seo; Ann Clin Nutr Metab 2023;15(3):67-71. Published online December 1, 2023; DOI: https://doi.org/10.15747/ACNM.2023.15.3.67

Abstract PDF

Purpose: Addressing both malnutrition and wound healing requires strategic intervention. However, guidelines for adequate nutrition for a variety of wounds are lacking. Based on the latest literature review, we summarize the role of nutrition in each stage of wound healing and nutritional recommendations for wound healing.
Current concept: Wounds undergo three healing phases: inflammatory, proliferative, and remodeling. The inflammatory phase involves clotting and cleaning the wound. The proliferative phase builds the wound bed through tissue growth. In the remodeling phase, collagen strength increases. Proper nutrition is crucial throughout. During inflammation, calcium, vitamin K, A, and E, zinc, and proteins are essential. In proliferation, amino acids, B vitamins, lipids, zinc, and iron play key roles. During remodeling, vitamins C and E, zinc, and water are critical for collagen synthesis and skin cell maturation. Vulnerable groups like the elderly, newborns, and obese patients need proper nutrition for skin maintenance. For pressure ulcers with malnutrition risk, recommendations are 30–35 kcal/kg/day energy, 1.25–1.5 g/kg/day protein, and 30 mL/kg water. Supplements might be added if regular meals don’t meet needs. For diabetic foot ulcers, despite common deficiencies, the 2019 International Working Group on the Diabetic Foot advises against prioritizing nutritional interventions over standard care due to limited high-quality evidence.
Conclusion: Despite limited guidelines, nutrition assessment is vital for wound evaluation. A multidisciplinary approach is key, emphasizing nutrition’s role in wound healing. Implementing nutritional interventions tailored to the wound and the individual’s nutritional status is essential. This comprehensive strategy ensures the best wound care outcomes.

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Cagney Cristancho, Kris M. Mogensen, Malcolm K. Robinson
Nutrition in Clinical Practice.2026; 41(1): 54. CrossRef
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Mengya Zhao, Zining Luo, Pengyan Tong, Yining Jia, Xin Yang, Jing Liu, Fangyu Long
Food Chemistry International.2026; 2(1): 46. CrossRef
Zinc supplementation and 60-day mortality in patients receiving total parenteral nutrition: a single-center experience
Mei-Yuan Liu, Chia-Yin Kuo, Hwung-Chung Lee, Jheng-Yan Wu
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Mohammad Ebrahim Astaneh, Narges Fereydouni
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Molly MacDonald, Christopher Stimson, Marti Samsel, Tina Gross
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Nanoformulations Loaded with Phytochemicals for Combating Wound Infections and Promoting Wound Healing: Current Applications and Innovations
Panoraia I. Siafaka, Androulla N. Miliotou, Mehmet Evren Okur, Gökçe Karaotmarlı Güven, Ioannis D. Karantas, Neslihan Üstündağ Okur
Applied Sciences.2025; 15(10): 5413. CrossRef
Combining Topical Oxygen and Negative-Pressure Wound Therapy: New Insights from a Pilot Study on Chronic Wound Treatment
Bartosz Molasy, Mateusz Frydrych, Rafał Kuchciński, Stanisław Głuszek
Journal of Clinical Medicine.2025; 14(15): 5564. CrossRef
Undifferentiated connective tissue dysplasia and skin: what to do? Dietitian’s position
E. A. Nikitina, S. V. Orlova, T. T. Batysheva, N. V. Balashova, M. V. Alekseeva
Medical alphabet.2025; 1(19): 60. CrossRef
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Chaoming Chen, Xuanfan Hu, Da He, Xuemei He, Lan Shen
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Aishik Banerjee, Arup Ghosh, Subhrajyoty Basu, Soumitra Sahana, Amit Kundu, Sumanta Mondal
Current Indian Science.2025;[Epub] CrossRef
Cancer-Related Malnutrition and Oxidative Stress in Colorectal Cancer Surgery: A Narrative Review of Pathophysiology and Postoperative Outcomes
Andrii Zahorodnii, Alicja Jelska, Paulina Głuszyńska, Hady Razak Hady
Antioxidants.2025; 14(11): 1289. CrossRef
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Patrick B. Wilson, David B. Pyne, Adrian Rotunno
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Young ran Kim, Mi young Jang, Jun ho Park
Clinical Nutrition Research.2025; 14(4): 241. CrossRef
Impact of Epigenetics, Diet, and Nutrition-Related Pathologies on Wound Healing
John Hajj, Brandon Sizemore, Kanhaiya Singh
International Journal of Molecular Sciences.2024; 25(19): 10474. CrossRef

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Body Compositions of Elderly and Non-Elderly Patients Following Gastrectomy for Gastric Cancer: Ji Hoon Kang, Mi Ran Jung, Sung Eun Kim, Oh Jeong; Ann Clin Nutr Metab 2022;14(2):81-87. Published online December 1, 2022; DOI: https://doi.org/10.15747/ACNM.2022.14.2.81

Abstract PDF: Purpose: Radical gastric resection is the mainstay of treatment in gastric cancer. However, patients can suffer from eating restrictions, weight loss, and malnutrition after gastrectomy, to which elderly patients are more vulnerable. We compared body composition changes in elderly patients and non-elderly patients after gastrectomy.
Materials and Methods: This prospective study enrolled patients who underwent gastrectomy for gastric carcinoma between 2019 and 2021. Body composition was measured using bioelectrical impedance analysis (InBody S10) before surgery and up to 12 months after surgery. Patients were divided into an elderly group (>70 years) and a non-elderly group (≤70 years), and body composition changes were compared between the two groups using the linear mixed model.
Results: There were 69 patients in the elderly group and 164 patients in the non-elderly group. The groups showed no significant differences in gastric resection or pathologic stage. Overall, body composition, including total body water, body weight, lean body mass, skeletal muscle mass, and fat mass, decreased immediately after surgery and gradually improved until postoperative 12 months. A linear mixed model showed no significant time×group interactions for any body composition factors between groups.
Conclusion: Body composition changes did not significantly differ between elderly patients and non-elderly patients after gastrectomy.

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Long-Term Changes of Body Mass Index and Nutritional Biochemical Markers in the Obese Elderly with Gastric Cancer: Eunjung Kim, Ji-Hyeon Park, Eun-Mi Seol, Seong-Ho Kong, Do Joong Park, Han-Kwang Yang, Hyuk-Joon Lee; Ann Clin Nutr Metab 2021;13(2):52-61. Published online December 31, 2021; DOI: https://doi.org/10.15747/ACNM.2021.13.2.52

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Nutritional Management in Dementia: Juhee Kang; J Clin Nutr 2021;13(1):1-6. Published online June 30, 2021; DOI: https://doi.org/10.15747/jcn.2021.13.1.1

Abstract PDF

With the increase in lifespan, and consequent increase in the elderly population, the prevalence of dementia is also increasing. The prevalence of dementia in the elderly over 65 in Korea was 10.3% in 2020 and is expected to increase to 16.1% by 2050. Dementia is a cognitive decline that affects eating behavior, leading to weight loss and malnutrition. In fact, the prevalence of malnutrition has been rising, and has been reported to be 58.9% among dementia patients in community facilities. Dementia requires the intake of sufficient calories and protein to prevent weight loss. On the other hand, intake of certain nutrients, such as omega-3 fatty acids, thiamine, vitamin E, selenium, and copper, helps prevent dementia in healthy people but has no effect on patients with advanced dementia. As dementia worsens, if food intake is reduced, oral nutritional supplements and enteral nutrition should be initiated to prevent weight loss and malnutrition. Dementia patients are very vulnerable to malnutrition, and hence require more active nutritional support.

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Development of 3D Printed Snack-dish for the Elderly with Dementia
Ji-Yeon Lee, Cheol-Ho Kim, Kug-Weon Kim, Kyong-Ae Lee, Kwangoh Koh, Hee-Seon Kim
Korean Journal of Community Nutrition.2021; 26(5): 327. CrossRef

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