Annals of Clinical Nutrition and Metabolism

Volume 15 (3); December 2023

Editorial

Association between sarcopenia and prognosis of hepatocellular carcinoma: Hae Il Jung; Ann Clin Nutr Metab 2023;15(3):65-66. Published online December 1, 2023; DOI: https://doi.org/10.15747/ACNM.2023.15.3.65

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Review

Role of nutrition in wound healing and nutritional recommendations for promotion of wound healing: a narrative review: Myoungjean Ju, Yoonhong Kim, Kyung Won Seo; Ann Clin Nutr Metab 2023;15(3):67-71. Published online December 1, 2023; DOI: https://doi.org/10.15747/ACNM.2023.15.3.67

Abstract PDF

Purpose: Addressing both malnutrition and wound healing requires strategic intervention. However, guidelines for adequate nutrition for a variety of wounds are lacking. Based on the latest literature review, we summarize the role of nutrition in each stage of wound healing and nutritional recommendations for wound healing.
Current concept: Wounds undergo three healing phases: inflammatory, proliferative, and remodeling. The inflammatory phase involves clotting and cleaning the wound. The proliferative phase builds the wound bed through tissue growth. In the remodeling phase, collagen strength increases. Proper nutrition is crucial throughout. During inflammation, calcium, vitamin K, A, and E, zinc, and proteins are essential. In proliferation, amino acids, B vitamins, lipids, zinc, and iron play key roles. During remodeling, vitamins C and E, zinc, and water are critical for collagen synthesis and skin cell maturation. Vulnerable groups like the elderly, newborns, and obese patients need proper nutrition for skin maintenance. For pressure ulcers with malnutrition risk, recommendations are 30–35 kcal/kg/day energy, 1.25–1.5 g/kg/day protein, and 30 mL/kg water. Supplements might be added if regular meals don’t meet needs. For diabetic foot ulcers, despite common deficiencies, the 2019 International Working Group on the Diabetic Foot advises against prioritizing nutritional interventions over standard care due to limited high-quality evidence.
Conclusion: Despite limited guidelines, nutrition assessment is vital for wound evaluation. A multidisciplinary approach is key, emphasizing nutrition’s role in wound healing. Implementing nutritional interventions tailored to the wound and the individual’s nutritional status is essential. This comprehensive strategy ensures the best wound care outcomes.

Citations

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Assessment of energy requirements in patients with obesity: A narrative review
Cagney Cristancho, Kris M. Mogensen, Malcolm K. Robinson
Nutrition in Clinical Practice.2026; 41(1): 54. CrossRef
Lueyang Black‐Boned Chicken and Black Bean Soup Promoting the Acute Healing of Skin Wounds, Accompanying Special Flavor Substances
Mengya Zhao, Zining Luo, Pengyan Tong, Yining Jia, Xin Yang, Jing Liu, Fangyu Long
Food Chemistry International.2026; 2(1): 46. CrossRef
Zinc supplementation and 60-day mortality in patients receiving total parenteral nutrition: a single-center experience
Mei-Yuan Liu, Chia-Yin Kuo, Hwung-Chung Lee, Jheng-Yan Wu
Frontiers in Nutrition.2026;[Epub] CrossRef
Electrospun-based nanofibers as ROS-scavenging scaffolds for accelerated wound healing: a narrative review
Mohammad Ebrahim Astaneh, Narges Fereydouni
International Journal of Polymeric Materials and Polymeric Biomaterials.2025; 74(15): 1349. CrossRef
Implementing a screening protocol for food insecure patients within a long‐term acute care hospital (LTACH): A community health needs assessment (CHNA)
Molly MacDonald, Christopher Stimson, Marti Samsel, Tina Gross
Nutrition in Clinical Practice.2025; 40(6): 1598. CrossRef
Nanoformulations Loaded with Phytochemicals for Combating Wound Infections and Promoting Wound Healing: Current Applications and Innovations
Panoraia I. Siafaka, Androulla N. Miliotou, Mehmet Evren Okur, Gökçe Karaotmarlı Güven, Ioannis D. Karantas, Neslihan Üstündağ Okur
Applied Sciences.2025; 15(10): 5413. CrossRef
Combining Topical Oxygen and Negative-Pressure Wound Therapy: New Insights from a Pilot Study on Chronic Wound Treatment
Bartosz Molasy, Mateusz Frydrych, Rafał Kuchciński, Stanisław Głuszek
Journal of Clinical Medicine.2025; 14(15): 5564. CrossRef
Undifferentiated connective tissue dysplasia and skin: what to do? Dietitian’s position
E. A. Nikitina, S. V. Orlova, T. T. Batysheva, N. V. Balashova, M. V. Alekseeva
Medical alphabet.2025; 1(19): 60. CrossRef
Nutritional Immunity in Wound Infection: Unveiling the Role of Dietary Elements in Host–Pathogen Interaction
Chaoming Chen, Xuanfan Hu, Da He, Xuemei He, Lan Shen
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Role of Nutrients and Diet in Wound Healing: The Emerging Paradigm for Effective Therapy
Aishik Banerjee, Arup Ghosh, Subhrajyoty Basu, Soumitra Sahana, Amit Kundu, Sumanta Mondal
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Cancer-Related Malnutrition and Oxidative Stress in Colorectal Cancer Surgery: A Narrative Review of Pathophysiology and Postoperative Outcomes
Andrii Zahorodnii, Alicja Jelska, Paulina Głuszyńska, Hady Razak Hady
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Clinical Impact of Nutritional Intervention on Pressure Injury Healing in a Paraplegic Patient: A Case Report
Young ran Kim, Mi young Jang, Jun ho Park
Clinical Nutrition Research.2025; 14(4): 241. CrossRef
Impact of Epigenetics, Diet, and Nutrition-Related Pathologies on Wound Healing
John Hajj, Brandon Sizemore, Kanhaiya Singh
International Journal of Molecular Sciences.2024; 25(19): 10474. CrossRef

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Original Articles

Body composition assessment using bioelectrical impedance analysis and computed tomography in patients who underwent pancreatoduodenectomy in Korea: a before and after study: Juwan Kim, Seung-seob Kim, Ho Kyoung Hwang, Chang Moo Kang, Kyung Sik Kim, Sung Hyun Kim; Ann Clin Nutr Metab 2023;15(3):72-80. Published online December 1, 2023; DOI: https://doi.org/10.15747/ACNM.2023.15.3.72

Abstract PDF Supplementary Material

Purpose: This study focuses on the need for standardized body composition measurements in the hepatobiliary-pancreatic field. It evaluates and compares the effectiveness of bioelectrical impedance analysis (BIA) and computed tomography (CT) scans in assessing body composition of patients undergoing pancreatoduodenectomy (PD), aiming to establish correlations among different body composition indexes.
Methods: Ninety-seven patients who underwent PD between August 2022 and March 2023, were enrolled in this study. Muscular and fatty parameters related to BIA and CT were assessed both preoperatively and on postoperative day 6. The correlation between each parameter related to muscle fat was analyzed according to the measurement modalities.
Results: There was an increase of skeletal muscle area (SMA), total muscle area, and low attenuated muscle area after surgery. Skeletal muscle mass (SMM) measured using BIA exhibited a strong correlation with the SMA and normal attenuated muscle area (NAMA) measured using CT (r=0.86, P<0.001; r=0.76, P<0.001). The trunk muscle measured using BIA demonstrated moderate to strong correlations with SMA and NAMA measured using CT (r=0.84 P<0.001; r=0.73, P<0.001). Body fat measured using BIA and total fat area (TFA) measured using CT showed strong correlations (r=0.74, P<0.001). In the postoperative analysis, a similar trend was observed (SMM vs. SMA: r=0.80, P<0.001; SMM vs. NAMA: r=0.70, P<0.001), (trunk muscle vs. SMA: r=0.79, P<0.001; trunk muscle vs. NAMA: r=0.69, P<0.001), and (body fat vs. TFA: r=0.83, P<0.001).
Conclusion: BIA, akin to CT, serves as a valuable tool for assessing body composition ratios in patients undergoing PD.

Citations

Citations to this article as recorded by

Morphomics in esophageal cancer: Validation and association with muscular and cardiorespiratory fitness
Watson Hua-Sheng Tseng, Shu-Chun Huang, Stewart C Wang, Jules Lin, Peng Zhang, Yu-Chen Liu, Yin-Kai Chao, Chien-Hung Chiu
World Journal of Gastrointestinal Surgery.2025;[Epub] CrossRef

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Perioperative nutritional practices and attitudes among gastrointestinal oncologic surgeons in Korea: a nation-wide survey study: Dae Hoon Kim, Jeong-Meen Seo, Min-Gew Choi; Ann Clin Nutr Metab 2023;15(3):81-87. Published online December 1, 2023; DOI: https://doi.org/10.15747/ACNM.2023.15.3.81

Abstract PDF Supplementary Material: Purpose: This study aimed to investigate the current perioperative nutritional practices and attitudes among gastrointestinal (GI) oncologic surgeons in Korea. Evidence-based perioperative nutritional practices are not well-established in this field.
Methods: A nationwide survey was conducted with 24 items, targeting GI oncologic surgical faculty members from March 2022 to April 2022 through social networking service messaging and email. Whole target number was 3,421.
Results: Out of responding 161 GI surgeons, 83.9% were male and 16.1% were female, and about 49.7% were in their 40s. When asked about their hospital policies, 67.1% reported the existence of formal nutritional screening programs. However, the execution and analysis of these programs varied considerably. Most surgeons conducted preoperative nutritional screening, with albumin testing the most frequently performed. In addition, nutritional supplementation—primarily protein drinks—was given before surgery. The duration for which these supplements were used varied from ≤3 days to 4–7 days. Most respondents recognized the importance of addressing nutritional deficiencies in patients with GI tumors; however, when asked about immunonutrition, 89.4% of surgeons admitted having limited knowledge.
Conclusion: Although there is recognition of the importance of evidence-based nutrition practices in GI and oncologic surgery programs, this study reveals limited implementation of such practices. This study highlights a considerable opportunity to leverage existing positive surgeon beliefs and published data on the benefits of perioperative nutrition to enhance surgical nutrition practices and to improve patient outcomes in Korea.

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Multi-biomarker approach to metabolic syndrome and associated diseases in Turkey: a cross sectional study: Semra Can Mamur, Omer Colak, Selma Metintas, Inci Arikan, Mehmet Kara; Ann Clin Nutr Metab 2023;15(3):88-96. Published online December 1, 2023; DOI: https://doi.org/10.15747/ACNM.2023.15.3.88

Abstract PDF: Purpose: Biomarker for cardiovascular diseases (CVDs) are important in the clinical monitoring of individuals with metabolic syndrome (MetS). The use of these biomarkers in combination may be predictive of CVDs. This study aimed to demonstrate the ability of multiple biomarkers to predict MetS, diabetes mellitus (DM), and CVDs. The use of multiple biomarkers instead of a single biomarker may be more useful in early diagnosis. We investigated the use of a multi-biomarker approach in MetS and associated diseases.
Methods: The study was performed by selecting control (n=30), MetS (n=30), MetS+DM (n=30), and MetS+CVD (n=30) groups from data of the Eskisehir Healthy Hearts Project conducted from January 2008 to October 2009 in Turkey. We recorded serum level of biomarkers, including lipid profile, liver enzyme, paraoxonase, arylesterase and arginase to find their difference among the groups.
Results: Compared to the control group, gamma-glutamyl transferase (GGT) and arginase levels increased, while paraoxonase and arylesterase activity and high-density lipoprotein–cholesterol levels were low in the patient groups (P<0.001). A negative correlation was observed between paraoxonase and arylesterase activity and MetS.
Conclusion: We believe that the combined use of biomarkers, including GGT, arginase, paraoxonase, and arylesterase, may be useful in predicting diseases such as MetS and CVDs.

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Comparative assessment of nutritional characteristics of critically ill patients at admission and discharge from the neurosurgical intensive care unit in Korea: a comparison study: Eunjoo Bae, Jinyoung Jang, Miyeon Kim, Seongsuk Kang, Kumhee Son, Taegon Kim, Hyunjung Lim; Ann Clin Nutr Metab 2023;15(3):97-108. Published online December 1, 2023; DOI: https://doi.org/10.15747/ACNM.2023.15.3.97

Abstract PDF

Purpose: Patients in neurosurgical (NS) intensive care units (ICUs) experience considerable energy and protein deficits associated with adverse outcomes. This study aimed to compare the nutritional status of patients at admission to (baseline) and discharge from the NS ICU.
Methods: This was a single-center, retrospective, before and after study of patients admitted in the NS ICU of the CHA Bundang Medical Center, from January 31, 2019, to February 28, 2020. All anthropometric data, biochemical data, clinical data, and dietary data were collected during the NS ICU stay. Specifically, we investigated the cumulative caloric deficit rate, phase angle and skeletal muscle index as indicators of lean muscle mass, and nitrogen balance according to demographic and clinical characteristics.
Results: A total of 140 NS patients were studied. Calf circumference decreased from 31.4±4.2 cm at baseline to 30.2±4.0 cm at discharge (P<0.001). Energy supply rate increased from 44.4% at baseline to 89.2% at discharge. Phase angle (PhA) patients with an modified Nutrition Risk in the Critically ill (mNUTRIC) score≤5 group had significantly lower PhA values than those with an mNUTRIC score>5 (P=0.005).
Conclusion: Although clinical and dietary parameters of patients in the NS ICU improved from baseline to discharge, anthropometric and biochemical markers of lean muscle mass and nutritional status decreased. PhA and nitrogen balance difference values were significantly different between those with an mNUTRIC score≤5 and those with an mNUTRIC score>5. These data indicate that the nutritional risk of critically ill patients increases during hospitalization in the NS ICU.

Citations

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Association between the Modified NUTRIC Score (mNUTRIC) and Clinical Outcomes in a Mixed Intensive Care Unit: A Retrospective Cohort Study
Thanh Luan Nguyen, Quang Dai Le, Trang Nguyen Hoai Dinh, Van Hoang Nam Ho, Cong Dang Tran, Van Phieu Duong, Hoang Ngoc Thao Duong, Phuc Tuong Pham, Thi Phuong Thao Le, Tuyet Phuong Bui
SN Comprehensive Clinical Medicine.2026;[Epub] CrossRef
Barriers to nutrition following neurosurgery: A descriptive cohort study
Dale Palmer, Melissa Zhou, Suzie Ferrie
Journal of Parenteral and Enteral Nutrition.2026;[Epub] CrossRef
A Review on the Effects of Multiple Nutritional Scores on Wound Healing after Neurosurgery.
Jingqian Ye, Bo Ning , Jianwen Zhi
International Journal of Biology and Life Sciences.2025; 9(2): 82. CrossRef
Transition from Enteral to Oral Nutrition in Intensive Care and Post Intensive Care Patients: A Scoping Review
Gioia Vinci, Nataliia Yakovenko, Elisabeth De Waele, Reto Stocker
Nutrients.2025; 17(11): 1780. CrossRef

4,521 View
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