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Original Articles
Early nutritional support for inpatients reduces admission rates to intensive care units in Korea: a single-center case-control study
Hyun Suk Kim, Jae Do Yang, Se Wung Han, Mi Rin Lee, Da-Sol Kim, Sejin Lee, Seon-Hyeong Kim, Chan-Young Kim
Ann Clin Nutr Metab 2024;16(2):57-65.   Published online August 1, 2024
DOI: https://doi.org/10.15747/ACNM.2024.16.2.57
AbstractAbstract PDFSupplementary MaterialePub
Purpose: Early nutritional support (ENS) for critically ill patients is promoted by many studies. However, there is a lack of data evaluating its necessity in general wards. This study aims to determine the impact of ENS on patients in general wards.
Methods: Patients aged 18 and above, admitted to the Jeonbuk National University Hospital in Jeonju from January 2020 to December 2020, who were eligible for nutritional support and hospitalized for at least 7 days were included in the study. We divided the patients into two groups: the ENS group, who received nutritional support within 48 hours of admission, and the control group, who received it after 48 hours.
Results: Among 1,077 patients, 146 met the inclusion criteria. The ENS group (n=38) and the control group (n=108) were compared retrospectively. There was a significant age difference between the two groups (P=0.028). The admission ratio to the intensive care unit (ICU) in the ENS group was significantly lower than that in the control group (10.2% vs. 26.3%, P=0.019). The calorie support rate (%) and protein support rate (%) in the ENS group were significantly higher than in the control group (50.12%±23.30% vs. 38.56%±18.02%, P=0.006; 44.61%±25.07% vs. 32.07%±22.76%, P=0.002, respectively). After propensity score matching, the ENS was significantly associated with ICU low admissions (odds ratio 0.08, 95% confidence interval 0.01–0.69, P=0.022).
Conclusion: A future multi-center study considering underlying diseases is needed to provide additional scientific evidence to support the effects of ENS.
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Perioperative nutritional practices and attitudes among gastrointestinal oncologic surgeons in Korea: a nation-wide survey study
Dae Hoon Kim, Jeong-Meen Seo, Min-Gew Choi
Ann Clin Nutr Metab 2023;15(3):81-87.   Published online December 1, 2023
DOI: https://doi.org/10.15747/ACNM.2023.15.3.81
AbstractAbstract PDFSupplementary Material
Purpose: This study aimed to investigate the current perioperative nutritional practices and attitudes among gastrointestinal (GI) oncologic surgeons in Korea. Evidence-based perioperative nutritional practices are not well-established in this field.
Methods: A nationwide survey was conducted with 24 items, targeting GI oncologic surgical faculty members from March 2022 to April 2022 through social networking service messaging and email. Whole target number was 3,421.
Results: Out of responding 161 GI surgeons, 83.9% were male and 16.1% were female, and about 49.7% were in their 40s. When asked about their hospital policies, 67.1% reported the existence of formal nutritional screening programs. However, the execution and analysis of these programs varied considerably. Most surgeons conducted preoperative nutritional screening, with albumin testing the most frequently performed. In addition, nutritional supplementation—primarily protein drinks—was given before surgery. The duration for which these supplements were used varied from ≤3 days to 4–7 days. Most respondents recognized the importance of addressing nutritional deficiencies in patients with GI tumors; however, when asked about immunonutrition, 89.4% of surgeons admitted having limited knowledge.
Conclusion: Although there is recognition of the importance of evidence-based nutrition practices in GI and oncologic surgery programs, this study reveals limited implementation of such practices. This study highlights a considerable opportunity to leverage existing positive surgeon beliefs and published data on the benefits of perioperative nutrition to enhance surgical nutrition practices and to improve patient outcomes in Korea.
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Review
Role of nutrition in wound healing and nutritional recommendations for promotion of wound healing: a narrative review
Myoungjean Ju, Yoonhong Kim, Kyung Won Seo
Ann Clin Nutr Metab 2023;15(3):67-71.   Published online December 1, 2023
DOI: https://doi.org/10.15747/ACNM.2023.15.3.67
AbstractAbstract PDF
Purpose: Addressing both malnutrition and wound healing requires strategic intervention. However, guidelines for adequate nutrition for a variety of wounds are lacking. Based on the latest literature review, we summarize the role of nutrition in each stage of wound healing and nutritional recommendations for wound healing.
Current concept: Wounds undergo three healing phases: inflammatory, proliferative, and remodeling. The inflammatory phase involves clotting and cleaning the wound. The proliferative phase builds the wound bed through tissue growth. In the remodeling phase, collagen strength increases. Proper nutrition is crucial throughout. During inflammation, calcium, vitamin K, A, and E, zinc, and proteins are essential. In proliferation, amino acids, B vitamins, lipids, zinc, and iron play key roles. During remodeling, vitamins C and E, zinc, and water are critical for collagen synthesis and skin cell maturation. Vulnerable groups like the elderly, newborns, and obese patients need proper nutrition for skin maintenance. For pressure ulcers with malnutrition risk, recommendations are 30–35 kcal/kg/day energy, 1.25–1.5 g/kg/day protein, and 30 mL/kg water. Supplements might be added if regular meals don’t meet needs. For diabetic foot ulcers, despite common deficiencies, the 2019 International Working Group on the Diabetic Foot advises against prioritizing nutritional interventions over standard care due to limited high-quality evidence.
Conclusion: Despite limited guidelines, nutrition assessment is vital for wound evaluation. A multidisciplinary approach is key, emphasizing nutrition’s role in wound healing. Implementing nutritional interventions tailored to the wound and the individual’s nutritional status is essential. This comprehensive strategy ensures the best wound care outcomes.
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Original Articles
Consultation pattern changes of parenteral nutrition with a multidisciplinary nutrition support team in a recently opened hospital in Korea: a retrospective cohort study
Kyoung Won Yoon, Hyo Jin Kim, Yujeong Im, Seul Gi Nam, Joo Yeon Lee, Hyo Gee Lee, Joong-Min Park
Ann Clin Nutr Metab 2023;15(2):57-63.   Published online August 1, 2023
DOI: https://doi.org/10.15747/ACNM.2023.15.2.57
AbstractAbstract PDF
Purpose: Parenteral nutrition (PN) is essential for the treatment of patients with malnutrition. The provision of central PN should be recommended by a nutrition support team (NST) made up of a team of experts, even in a newly established hospital. This study sought to evaluate the effectiveness of PN delivered by a multidisciplinary NST in a recently opened hospital.
Methods: This was a retrospective study of the effectiveness of a central PN recommendation pop-up message by the electronic medical record (EMR) software to prompt physicians to either calculate the required calorie and protein intake or consult with the NST. The study period was divided into pre-NST and post-NST based on the time of recruitment of NST-dedicated personnel.
Results: Patients in the 12-week pre-NST period (n=50) and 12-week post-NST period (n=74) were compared retrospectively. Baseline characteristics were not significantly different between the two groups, except for the median Acute Physiology and Chronic Health Evaluation II score (pre-NST group, 8 [interquartile range, IQR 5–15.5] vs. post-NST group, 15 [IQR 9–24], P=0.012) of the 45 patients total admitted to the intensive care unit. The percentage of patients for whom physicians requested a consultation with the NST for central PN was significantly higher in the post-NST group (52.0% vs. 75.7%, P=0.011). There was no significant difference in achievement of nutrition targets or mortality.
Conclusion: Building a multidisciplinary NST may increase awareness of nutritional status and affect the behavior of physicians in recently-opened hospitals.
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Effects of nutritional status and support on the survival of COVID-19 patients in a single tertiary-center intensive care unit in Korea: a case-control study
Na Gyeong Lee, Hye Jin Kim, Ji Gyeong Kang, Do Hyeon Jeon, Mi Seung Kwak, So Hyun Nam
Ann Clin Nutr Metab 2023;15(1):30-37.   Published online April 1, 2023
DOI: https://doi.org/10.15747/ACNM.2023.15.1.30
AbstractAbstract PDF
Purpose: It is important to understand the nutritional status of critically ill COVID-19 patients and to provide adequate associated support. We attempted to determine how nutritional status and the amount of nutritional support provided to critically ill patients affect their survival.
Methods: We retrospectively reviewed the medical records of patients admitted to the intensive care unit of Dong-A University Hospital between January and December 2021. We divided the patients into survivors and those who died during COVID-19 treatment and compared and analyzed their clinical parameters, nutrition-related indicators, nutritional status, and nutritional support.
Results: Of 70 patients reviewed, 57 survived. Mortality was higher in the older group (P=0.006). The patients who underwent ventilator, extracorporeal membrane oxygenation, or continuous renal replacement therapy showed higher mortality. Nutritional status at the time of admission and the nutritional requirements did not differ among patient groups. However, the actual amounts of calories (P<0.001) and protein (P=0.019) supplied were lower in the mortality group. Serum C-reactive protein level was higher (P=0.002) and serum albumin level was lower in those who did not survive (P<0.001) compared with surviving patients at discharge.
Conclusion: We did not determine whether the initial nutritional status of patients with COVID-19 affected their survival due to various factors associated with the severity of the disease. However, given the similarities between disease severity and nutritional status at the time of admission, our results indicate that adequate nutritional support can contribute to survival in critically ill COVID-19 patients with pneumonia.
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Case Report
Refeeding Syndrome after Gastrectomy in a Patient with Hypophosphatemia: A Case Report
Cheong Ah Oh
Ann Clin Nutr Metab 2022;14(2):88-92.   Published online December 1, 2022
DOI: https://doi.org/10.15747/ACNM.2022.14.2.88
AbstractAbstract PDF
This study describes an 81-year-old male who was highly suspicious for refeeding syndrome (RFS) after a retrospective review of his postoperative clinical progression. This highlights the importance of clinicians’ awareness of the possibility of RFS development in surgical patients with any RFS risk factors.
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Review Article
Liver Cirrhosis and Sarcopenia
Hye Yeon Chon, Tae Hee Lee
Ann Clin Nutr Metab 2022;14(1):2-9.   Published online June 1, 2022
DOI: https://doi.org/10.15747/ACNM.2022.14.1.2
AbstractAbstract PDF
Malnutrition is one of the most common complications in patients with liver cirrhosis. In previous studies, cirrhotic patients with severe malnutrition have been associated with higher morbidity and mortality rates before and after liver transplantation. Frailty and sarcopenia are phenotypes of severe malnutrition that have been associated with complications requiring hospitalization or mortality during the wait for transplantation in patients with cirrhosis. Tools for evaluating frailty include the Activities of Daily Living scale, the Karnofsky Performance Status scale, and the Liver Frailty Index. Diagnosed by using computed tomography, sarcopenia is measured with the skeletal muscle index at L3 and is normalized by height. Nutritional status should be evaluated within the first 24~48 hours of hospitalization in every patient with cirrhosis. Among the various available screening tools, the Royal Free Hospital-Nutritional Prioritizing Tool proposed in the UK is recommended. Nutritional counseling with a multidisciplinary team is recommended to improve long-term survival in patients with cirrhosis. Multidisciplinary nutrition management should include evaluating nutritional status and providing guidance for achieving nutritional goals. Most guidelines suggest a calorie intake of 25~35 kcal/kg/day, and the recommended protein intake is 1.2~1.5 g/kg/day. One beneficial technique for patients is to divide the total recommended intake across four to five daily meals, including a nighttime snack. The principles of nutritional intervention in cirrhotic patients are not different from those in noncirrhotic patients. For improvement of sarcopenia, a strategic approach including physical activity and exercise, hormone replacement therapy, ammonia-lowering agents, and treatment of underlying liver disease is required.
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Original Article
Clinical Significance of Malnutrition Risk in Severe Trauma Patients: A Single-Center Study
Hohyun Kim, Kum-Hee Hong, Inah Choi, Kyung-A Lee, Geun Am Song
Ann Clin Nutr Metab 2021;13(2):68-74.   Published online December 31, 2021
DOI: https://doi.org/10.15747/ACNM.2021.13.2.68
AbstractAbstract PDF
Purpose: A suboptimal nutritional status is often observed among hospitalized patients across all medical/surgical specialties. The objective of the present study was to (1) analyze the prevalence of malnutrition in severe trauma patients and (2) evaluate the relationship between malnutrition and select clinical outcomes.
Materials and Methods: This retrospective study was conducted between October 2015 and March 2017 at the Pusan National University Hospital Trauma Center. Of a total of 3,560 patients, 945 were enrolled in this study. Patients were checked for malnutrition using a nutrition assessment tool by the hospital nutrition support team. The parameters assessed included serum albumin, the ratio of actual body weight to ideal body weight (%), total lymphocyte count, appetite, and gastrointestinal problems. Clinical outcomes under consideration included 1) mortality, 2) length of hospitalization, and 3) length of stay in the intensive care unit (ICU).
Results: The total prevalence of malnutrition in hospitalized trauma patients was 55.0% (n=520). Malnutrition risk was the independent prognostic factor of mortality in severe trauma patients (adjusted odds ratio [OR]=3.440; 95% confidence interval [CI]=1.401~8.447, P=0.007). Risk factors of malnutrition were age over 65 years (adjusted OR=2.393; 95% CI=1.699~3.370, P<0.001), injury severity score (adjusted OR=1.034, 95% CI=1.012~1.056, P=0.002), length of hospitalization (adjusted OR=1.104; 95% CI=1.007~1.020, P<0.001), and length of stay in the ICU (adjusted OR=1.050; 95% CI=1.029~1.072, P<0.001).
Conclusion: Malnutrition is widespread in hospitalized patients with severe trauma and results in suboptimal clinical outcomes. Thus, patients at high risk of malnutrition should be monitored carefully during hospitalization.
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Review Articles
Perioperative Nutritional Support
Seung Jong Oh
J Clin Nutr 2021;13(1):7-11.   Published online June 30, 2021
DOI: https://doi.org/10.15747/jcn.2021.13.1.7
AbstractAbstract PDF
Malnutrition in surgical patients is a prevalent problem. As the geriatric population gradually increases, surgeons need to be more careful in preventing the risk of iatrogenic malnutrition. Delayed wound healing, exposure to infection, pressure sores, gastrointestinal bacterial overgrowth, and immunosuppression in malnourished patients can be prevented or diminished with active nutritional support. Preoperative nutritional assessment and support, as well as adequate postoperative nutrition, will improve surgical outcomes, which in turn will lead to fewer postoperative complications, shorter hospital stays, and lower medical costs. The success of surgery depends not only on technical surgical skills but also on metabolic interventions that take into account the patient’s ability to deliver the metabolic load and provide adequate nutritional support.
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Nutritional Management in Dementia
Juhee Kang
J Clin Nutr 2021;13(1):1-6.   Published online June 30, 2021
DOI: https://doi.org/10.15747/jcn.2021.13.1.1
AbstractAbstract PDF
With the increase in lifespan, and consequent increase in the elderly population, the prevalence of dementia is also increasing. The prevalence of dementia in the elderly over 65 in Korea was 10.3% in 2020 and is expected to increase to 16.1% by 2050. Dementia is a cognitive decline that affects eating behavior, leading to weight loss and malnutrition. In fact, the prevalence of malnutrition has been rising, and has been reported to be 58.9% among dementia patients in community facilities. Dementia requires the intake of sufficient calories and protein to prevent weight loss. On the other hand, intake of certain nutrients, such as omega-3 fatty acids, thiamine, vitamin E, selenium, and copper, helps prevent dementia in healthy people but has no effect on patients with advanced dementia. As dementia worsens, if food intake is reduced, oral nutritional supplements and enteral nutrition should be initiated to prevent weight loss and malnutrition. Dementia patients are very vulnerable to malnutrition, and hence require more active nutritional support.
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Original Articles
Nutritional Support Team Approach Decreases the In-Hospital Mortality Rate after Deceased Donor Liver Transplantation
Sang-Oh Yun, Jong Man Kim, Sangjin Kim, Jinsoo Rhu, Hyun Jung Kim, Soo Hyun Park, Hyo Jung Park, Eunmi Gil, Wonseok Kang, Gyu-Seong Choi, Won Hyuck Chang, Jeong-Meen Seo, Jae-Won Joh
Surg Metab Nutr 2020;11(1):7-11.   Published online June 30, 2020
DOI: https://doi.org/10.18858/smn.2020.11.1.7
AbstractAbstract PDF
Purpose: This study compared the mortality rates between a period of time without employing a nutritional support team (NST) and a period of time with an NST.
Materials and Methods: Forty-six patients underwent adult deceased donor liver transplantation (DDLT) in 2016, and their medical records were prospectively collected. All the donor recipients underwent routine enteral feeding after liver transplantation. An NST cared for twenty-one patients after September 2016. The NST consisted of transplant surgeons, hepatologists, a critical care team, a rehabilitation team, dietitians, pharmacists, and nurses. We defined the patients within the time period without an NST as the control group and those patients within the time period with an NST as the case group.
Results: There were no statistically significant differences in baseline or perioperative characteristics between the two groups. The median model for the end-stage liver disease (MELD) score was 36 (range: 21∼40) for the control group and 36 (range: 23∼40) for the case group (P=0.596). The 30-day mortality rate was 24.0% (6/25) for the control group, but it was 4.8% (1/20) for the case group. The patient survival rates at 1-year and 2-year were 68.0% and 64.0% in the control group and 85.7% and 81.0% in the case group, respectively. However, there were no statistically significant differences of the 30-day mortality rate and 1∼2 year patient survival rate between the two groups.
Conclusion: The present study suggests that an NST should be required to prevent 30-day mortality and increase patient survival of adult DDLT patients with a high MELD score.
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Analysis of the Factors Related to the Incidence and Aggravation of Pressure Ulcers for in Patients from a Nutritional and Clinical Perspective
Yoon Young Choi, Han Mo Yoo, Young Hwa Kim, Jeong Goo Kim
Surg Metab Nutr 2020;11(1):16-21.   Published online June 30, 2020
DOI: https://doi.org/10.18858/smn.2020.11.1.16
AbstractAbstract PDF
Purpose: The incidence of pressure ulcers has reached significant proportions in ward patients. Considering the increasing proportion of older patients, it is important to know the factors associated with pressure ulcers. The purpose of this study was to investigate the association between nutritional status patients and the prognosis of pressure ulcers.
Materials and Methods: Four hundred patients who had their nutritional status evaluated from December 2015 to May 2016 at Daejeon St. Mary’s Hospital were enrolled in this study. The Modified NRS 2002 was used to address the nutritional status. Pressure ulcers were evaluated using the PUSH score, and the nutritional factors were evaluated with pressure ulcer aggravation.
Results: Among the 400 patients who had their nutritional status evaluated, 174 (43.5%) had a pressure ulcer. A high risk of malnutrition was associated significantly with the incidence of pressure ulcers. In patients with pressure ulcers, the necessity of a nutritional support team approach (odds ratio [OR], 2.43; 95% confidence interval [CI], 1.21∼4.91; P=0.01) and the number of pressure ulcers (odds ratio [OR], 3.79; 95% confidence interval [CI], 1.81∼7.91; P<0.001) were risk factors for pressure ulcer aggravation.
Conclusion: These results indicate that a proper evaluation of the malnutrition state and obtaining a nutritional support team intervention are important for preventing the aggravation of pressure ulcers. Furthermore, if a patient has multiple sites of pressure ulcers, a careful assessment will be needed to prevent their deterioration.
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Risk of Malnutrition after Gastrointestinal Cancer Surgery: A Propensity Score Matched Retrospective Cohort Study
Sung-Hoon Yoon, Bong-Hyeon Kye, Hyung-Jin Kim, Kyong-Hwa Jun, Hyeon-Min Cho, Hyung-Min Chin
Surg Metab Nutr 2018;9(1):16-25.   Published online June 30, 2018
DOI: https://doi.org/10.18858/smn.2018.9.1.16
AbstractAbstract PDF

Purpose:

Patients with cancers arising from the gastrointestinal tract can suffer from nutritional inadequacies caused by various factors. This study investigated the risk of malnutrition after curative surgery in patients with gastric cancer (GC) or colorectal cancer (CRC) using various preoperative and postoperative nutritional screening tools.

Materials and Methods:

In the authors’ hospital, 407 patients (206 patients with GC and 201 patients with CRC) underwent surgery between July 2011 and June 2012. The patients from the two groups were matched using the propensity score and then analyzed the nutritional data from 170 patients (85 patients in each group), retrospectively.

Results:

In both groups, the postoperative nutritional status was impaired significantly compared to the preoperative status. The postoperative risk of undernutrition in CRC patients was significantly lower than that of the GC patients according to the Malnutrition Universal Screening Tool (P=0.007). At the time of hospital discharge after surgery, the incidence of a lower serum albumin level (P=0.002) and more than 5% weight loss (P=0.013) were higher in the GC group than in the CRC group. A comparison of the postoperative nutritional status among the types of surgery in each group, total gastrectomy in the GC group (P=0.015) and proctectomy with diverting stoma in the CRC group (P=0.06), were related to more than 5% weight loss.

Conclusion:

Gastrointestinal cancer surgery might increase the patients’ postoperative risk of malnutrition, particularly in GC surgery. Therefore, consecutive assessments of the nutritional status and appropriate nutritional support are necessary after surgery for GC and CRC.

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Quality Improvement Activities to Facilitate the Filing of Complexity Payment Claims for Patients with Malnutrition
Kuk Hwan Kwon, Hyung Soon Lee, Jee Hyoung Yoo, Soo Na Chi, Hyun Hee Park, So Won Kim, Kyung Ran Kim, Nan Hee Yun, Kyoung Taek Ra, Hyun Jung Song
J Clin Nutr 2018;10(1):20-24.   Published online June 30, 2018
DOI: https://doi.org/10.15747/jcn.2018.10.1.20
AbstractAbstract PDF

Purpose:

The grade of complexity in the diagnosis related group (DRG) payment system is influenced by the secondary diagnosis of specific complication and comorbidity level, in which moderate or severe malnutrition is included. This study examined an existing proportion of patients with malnutrition who were supposed to be qualified for the complexity level and devised quality improvement measures to increase the proportion of qualifying complexity payments.

Methods:

The goal of the activities was to increase the rate of complexity payment claims for patients with malnutrition (%). Cases ineligible for the DRG payment system and cases with no diagnosis of malnutrition were excluded. We established a collaborative system between the nutrition support team and departments related to each improvement factor (i.e., patient care, medical records, insurance review, and medical information).

Results:

Before implementing the activities, this study investigated the current level of complexity payment claims for malnutrition patients who were discharged within a specific period (June 1, 2015∼August 31, 2015). The results showed that complexity payment claims were filed in 10.00% (2 of the 20 malnutrition cases). After the activities, the rate of complexity payment claims for the patients with malnutrition within the study period (June 1, 2016∼August 31, 2016) was 46.43% (26 out of 56), showing an approximately 364% increase from the pre activity rate. This change was statistically significant according to the chi-square test on Microsoft Excel 2010 (P<0.01).

Conclusion:

Collaborative efforts by the related departments enabled the smooth implementation of each activity. In addition, moderate or severe malnutrition was revealed to be a variable in the complexity-specific payment system. In the future, hospital-wide awareness and effort are crucial to promot the steady practice of these activities and expand their implementation.

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Review Articles
Nutritional Support for Pediatric Patients with Biliary Atresia
Joong Kee Youn, Ji-Young Song, Hyun-Young Kim
J Clin Nutr 2017;9(2):56-61.   Published online December 31, 2017
DOI: https://doi.org/10.15747/jcn.2017.9.2.56
AbstractAbstract PDF

Biliary atresia (BA) is a major cause of extrahepatic biliary obstruction in children. Malnutrition is a significant clinical problem in children with BA. BA may induce the malabsorption of fat and fat-soluble vitamins, resulting in cholestasis and an impaired nutritional status. For the treatment of BA, it is most important to reconstruct the bile flow as early as possible by performing a Kasai portoenterostomy. After the Kasai operation, growth and nutrition are restored, but to follow normal growth and development, it is necessary to evaluate the nutritional status and support. Therefore, the purpose of nutritional support in children with BA is to normalize growth and development, prevent further liver damage and deterioration of the patient’s nutritional status, avoid vitamin and mineral deficiencies, and improve the quality of life of patients.

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Nutritional Management in Patients with Liver Dysfunction
Tae Hee Lee
Surg Metab Nutr 2017;8(1):1-6.   Published online June 30, 2017
DOI: https://doi.org/10.18858/smn.2017.8.1.1
AbstractAbstract PDF

Liver disease and nutritional status are known to affect each other. When liver disease is severe, patients become more malnourished and have a worse prognosis. Adequate nutritional support for patients with liver diseases can improve a patient’s condition and prognosis. In acute liver failure, malnutrition is uncommon, and the disease prognosis is determined within a short time. Patients with acute liver failure may survive and recover if they receive a transplant. Considerations should be given to the management of glucose intolerance and hyperammonemia. However, well-designed clinical trials are still lacking until now. In the case of liver cirrhosis, malnutrition may occur due to a variety of causes, and as in other diseases, oral or enteral nutrition is preferred to parenteral nutrition. Even if esophageal varices are present, it is possible to install a feeding tube. However, in the presence of ascites, PEG (percutaneous endoscopic gastrostomy) becomes contraindicated due to risk of complications. Calorie intake of 30~35 Kcal/kg/day and protein intake of 1.2 to 1.5 g/kg/day are appropriate. Protein restriction should not be necessary unless hepatic encephalopathy is severe. Late evening snacking and intake of branched chain amino acids can be helpful.

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Original Articles
Evaluation on the Time to Start Parenteral Nutrition in Hospitalized Cancer Patients
Nam Hyo Kim, Hyo Jung Park, Yong Won In, Young Mee Lee
J Clin Nutr 2017;9(1):30-35.   Published online June 30, 2017
DOI: https://doi.org/10.15747/jcn.2017.9.1.30
AbstractAbstract PDF

Purpose:

Malnutrition is quite prevalent in hospitalized cancer patients, with a 40%∼80% rate. Malnutrition in cancer patients can result in an increase in the number of complications, length of stay, mortality, and morbidity. Therefore, cancer patients with malnutrition must have the appropriate nutritional support to improve the prognosis of cancer. This study evaluated the appropriate time point to start parenteral nutrition (PN) after admission according to the nutrition support guidance in Samsung Medical Center.

Methods:

This study enrolled patients diagnosed with the Korean standard classification of disease 6 (KCD6) code C00-C97 and discharged from March 1st to 31st, 2016. The following data were collected: patients’ age, gender, diagnosis, length of stay, body mass index, nutritional status, and whether to consult nutrition support team (NST).

Results:

Among a total of 2,944 patients, 381 patients (12.9%) were in a malnourished status upon admission. In the malnourished patients, 139 patients were prescribed PN for a median of 6 days (range, 1∼49) and moderate to severe malnourished patients were started on PN within 2 days after admission. The proportion of patients with a poor nutritional status was lower in the NST group than in the non-NST group (50.0% vs. 66.7%) on the 28th day after admission. Among the nourished patients, 229 patients were prescribed PN. Of them, 183 patients (79.9%) were started on PN within 7 days after admission.

Conclusion:

In moderate to severe malnourished cancer patients, the initiation of PN on the day after admission is appropriate.

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Enteral Nutrition Support in Coronary Care Unit Patients Receiving Extraocorporeal Membrane Oxygenation: An Observational Case Study
Sung Hye Kim, Yoonjin Shin, Mi Yong Rha, Young Yun Cho, Jeong Hoon Yang, Yang-Hyun Cho, Ji Young Seo, Bori Kang, Yangha Kim
J Clin Nutr 2016;8(3):77-83.   Published online December 31, 2016
DOI: https://doi.org/10.15747/jcn.2016.8.3.77
AbstractAbstract PDF

Purpose:

Enteral feeding remains controversial in patients receiving extracorporeal membrane oxygenation (ECMO), particularly in those treated with a high-dose vasopressor. This study examined the safety and feasibility of enteral nutritional support for patients undergoing ECMO in a cardiac care unit (CCU).

Methods:

Adult patients admitted to the CCU undergoing ECMO from January 2014 to May 2015 were included. Patients with <48 hours of support, undergoing ECMO at another hospital, and inaccurate medical records were excluded.

Results:

Among the 14 patients undergoing ECMO in the CCU, 2 patients were diagnosed with malnutrition and the others were in the normal state in the initial assessment. On the other hand, they had the malnutrition risk factors (anorexia, weight loss, fluid retention, and hypermetabolic state). Thirteen patients received enteral nutrition and 1 patient had possible oral intake. The average initiation day of enteral nutrition was 2.0±1.6 days on ECMO. The mean duration of enteral nutrition was 5.2±4.9 days and the target goal was achieved within 3 days. There were no serious adverse effects for enteral nutrition but 3 patients had gastrointestinal problems (diarrhea and anorexia), and gastrointestinal bleeding occurred in 1 patient. In 1 case, enteral nutrition had to be stopped due to the prone position. Overall, 5 patients were cured, 3 patients recovered through heart transplantation, and 6 patients died.

Conclusion:

Most CCU patients receiving ECMO were well nourished but had the malnutrition risk factors in progress. These results suggest that enteral feeding might be safe and feasible in patients treated with ECMO but there were minor side effects.

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Review Articles
Micronutrients Deficiencies in Bariatric Patients
Yeon Ji Lee
Surg Metab Nutr 2016;7(1):7-12.   Published online June 30, 2016
DOI: https://doi.org/10.18858/smn.2016.7.1.7
AbstractAbstract PDF

Paradoxically, the obese are more susceptible to malnutrition. The more obese they are, the greater the risk for micronutrient deficiencies particularly in fat-soluble vitamins and anti-oxidants. Several micronutrient deficiencies could be worsened because of poor intake and absorption difficulty after bariatric surgery. Micronutrient deficiencies could not only decrease the effect of bariatric surgery but also cause various diseases such as anemia, neurologic impairment, or osteoporosis. Micronutrient deficiencies should be monitored, recognized, and corrected properly in bariatric patients in order to maximize the effect of surgery and improve the health-related quality of life.

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Nutritional Screening Tool for In-Hospital Patients
Eunmi Seol, Dal Lae Ju, Hyuk-Joon Lee
J Clin Nutr 2016;8(1):2-10.   Published online April 30, 2016
DOI: https://doi.org/10.15747/jcn.2016.8.1.2
AbstractAbstract PDF

Malnutrition is a common problem in hospital settings. A poor nutritional status has been associated with higher rates of infection, poor wound healing, longer hospital stays, and higher hospital costs. Therefore, early recognition and timely treatment of malnutrition is vital. To identify malnourished individuals or those at risk of becoming malnourished, selecting and validated a uniform screening tool is clearly an important issue. Both the Nutritional Risk Screening-2002 (NRS-2002) and Malnutrition Universal Screening Tool (MUST) are recommended by the European Society for Parenteral and Enteral Nutrition (ESPEN) for a hospital setting. For older patients, the Mini Nutritional Assessment (MNA) is the recommended tool. Short Nutrition Assessment Questionnaire (SNAQ) and Malnutrition Screening Tools (MST) are brief and simple screening tools that use self-reported queries of variables that include weight loss and poor appetite. On the other hand, many of those require considerable time and labor to administer and may not be highly applicable to a Korean population. In Korea, most hospitals use a computerized nutritional screening system with a self-developed nutrition screening index. The variables for the tools, which are based on each hospital setting, include the objective data available in the patient’s medical records and limited information collected from the nursing admission questionnaire. The application of different tools hampers any comparison of the malnutrition prevalence between different settings and patients groups. In addition, the absence of a widely accepted malnutrition screening tool hinders both effective recognition and the treatment of malnutrition. Therefore, the development of uniform and valid screening tools and effective nutritional support programs for Korean malnourished patients is needed.

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Original Article
Analysis of Current Use of Early Parenteral Nutrition and Clinical Significance of Non-protein Calorie: Nitrogen in Surgical Critically Ill Patients
Eunjeong Heo, Kayoung Park, Sujeong Jeon, Hyungwook Namgung, Eunsook Lee, Inae Song
J Clin Nutr 2015;7(3):75-80.   Published online December 31, 2015
DOI: https://doi.org/10.15747/jcn.2015.7.3.75
AbstractAbstract PDF

Purpose:

Surgical critically ill patients require adequate nutrition support and the American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) guidelines recommend low non-protein calorie:nitrogen ratio (NPC:N ratio, 70∼100) for critically ill pateints. In this study, we assess the current use of early parenteral nutrition of surgical critically ill patients and analyze the clinical significance of NPC:N.

Methods:

This is a retrospective study of critically ill adult patients who remained in the intensive care unit (ICU) for over 3 days and could not receive enteral nutrition for the first 7 days. Data on parenteral intake of patients were collected from electronic medical records. Association of NPC:N scores with clinical outcome (length of ICU stay, length; of hospital stay, duration of ventilation, and mortality) were analyzed using Pearson correlation and multiple regression.

Results:

The study included 72 cases, average parenteral calorie intake was 14.6 kcal/kg/day and protein intake was 0.5 g/kg/day. We assessed the NPC:N scores to determine the patients’ NPC:N for the first 7 days in ICU close to the A.S.P.E.N guidelines. NPC:N scores showed weak negative correlation with length of hospital stay and duration of mechanical ventilation (r=−0.259, P=0.028; r=−0.495, P=0.001). Multiple regression adjusted with APACHE (Acute Physiology and Chronic Health Evaluation) II score, age, and body mass index showed correlation of higher NPC:N score with decreased length of hospital stay and shorter duration of ventilation (P=0.0001, P=0.035, respectively). However, length of ICU stay and mortality within 60 days showed no significant correlation with NPC:N scores.

Conclusion:

Parenteral calories and protein intakes of critically ill patients in ICU were lower in comparison to A.S.P.E.N. recommendation in this study. Low NPC:N scores might be related to shorter length of hospital stay, duration of mechanical ventilation. Consultation of a nutritional support team could have a positive effect in providing appropriate nutrition support.

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Review Article
Reimbursement of Nutritional Support Team, What Is the Problem and How Can We Manage It?
Dongwoo Shin
J Clin Nutr 2015;7(1):2-8.   Published online April 30, 2015
DOI: https://doi.org/10.15747/jcn.2015.7.1.2
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Korea Ministry of Health and Welfare launched legislation for reimbursement for Nutrition Support Team (NST) activities from August 1st, 2014, which can be applied as a flat rate fee per day once a week. The indicated patients are those with hypoalbuminemia, on parenteral nutrition or enteral nutrition, critically ill patients in intensive care unit’s, and any patient on suspicion of malnutrition by the physician in charge. NST should be comprised of a professional physician, an educated nurse, an educated pharmacist, and a professional and experienced dietitian. The maximum number of patients that can be treated by one NST is 30 per day. Such a reimbursement system has resulted in some complex problems with NSTs. The low price does not provide adequate reward for the team’s workload because the output of NST belongs to the department in charge and there is no ensured incentive. The Department of Health Insurance Review and Assessment Service cannot detect the quality problem of NST, non-compliance of physicians in charge. There are no stratified codes according to severity of disease and no difference between the first visit and the repeated visit. Every NST should be certified with accreditation and should participate in a qualified education program. Korea Health Insurance does not cover the fees for feeding tubes, formulas, and pumps. Evidence that NST activities can reduce medical cost of hospital-admitted in-patients is needed. Cost-effectiveness can be achieved by quality improvement of NST.

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Ann Clin Nutr Metab : Annals of Clinical Nutrition and Metabolism
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